BS7299

antibody from Bioworld Technology, Inc
Targeting: NR0B2 SHP
Provider product page for BS7299
Western blot
Immunohistochemistry

Antibody data

Product number
BS7299 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NR0B2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NR0B2.
Description
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NR0B2 protein structure - BS7299 shown in red.