Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14994-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14994-1-AP, RRID:AB_2142013
- Product name
- METTL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated METTL1 antibody (Cat. #14994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prognostic role of METTL1 in glioma.
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.
Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation.
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Li L, Yang Y, Wang Z, Xu C, Huang J, Li G
Cancer cell international 2021 Nov 27;21(1):633
Cancer cell international 2021 Nov 27;21(1):633
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.
Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T, Bi J, Huang X, Liu R, Huang L, Luo Y, Li W, Lin S
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3422-3435
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3422-3435
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
Dai Z, Liu H, Liao J, Huang C, Ren X, Zhu W, Zhu S, Peng B, Li S, Lai J, Liang L, Xu L, Peng S, Lin S, Kuang M
Molecular cell 2021 Aug 19;81(16):3339-3355.e8
Molecular cell 2021 Aug 19;81(16):3339-3355.e8
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI
Molecular cell 2021 Aug 19;81(16):3323-3338.e14
Molecular cell 2021 Aug 19;81(16):3323-3338.e14
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.
Wang C, Wang W, Han X, Du L, Li A, Huang G
Oncology letters 2021 Apr;21(4):330
Oncology letters 2021 Apr;21(4):330
Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation.
Malbec L, Zhang T, Chen YS, Zhang Y, Sun BF, Shi BY, Zhao YL, Yang Y, Yang YG
Cell research 2019 Nov;29(11):927-941
Cell research 2019 Nov;29(11):927-941
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI
Molecular cell 2018 Jul 19;71(2):244-255.e5
Molecular cell 2018 Jul 19;71(2):244-255.e5
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Okamoto M, Fujiwara M, Hori M, Okada K, Yazama F, Konishi H, Xiao Y, Qi G, Shimamoto F, Ota T, Temme A, Tatsuka M
PLoS genetics 2014 Sep;10(9):e1004639
PLoS genetics 2014 Sep;10(9):e1004639
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 14994-1-AP(METTL1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14994-1-AP(METTL1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The METTL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human METTL1. This antibody recognizes human, mouse, rat antigen. The METTL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.