Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 16754-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16754-1-AP, RRID:AB_2160031
- Product name
- PCK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PCK1 antibody (Cat. #16754-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Gliquidone ameliorates hepatic insulin resistance in streptozotocin-induced diabetic Sur1-/- rats.
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase.
Functionalized Gadofullerene Ameliorates Impaired Glycolipid Metabolism in Type 2 Diabetic Mice.
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice.
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
LncRNA GA-Binding Protein Transcription Factor Subunit Beta-1 Antisense RNA 1 Inhibits Renal Carcinoma Growth Through an MiR-1246/Phosphoenolpyruvate Carboxykinase 1 Pathway.
PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress.
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance.
Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output.
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.
A novel immunodeficient rat model supports human lung cancer xenografts.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.
Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats.
Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Role of AMPD2 in impaired glucose tolerance induced by high fructose diet.
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.
Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens.
Zhang R, Zhou X, Sheng Q, Zhang Q, Xie T, Xu C, Zou Z, Dong J, Liao L
European journal of pharmacology 2021 Sep 5;906:174221
European journal of pharmacology 2021 Sep 5;906:174221
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase.
Figlak K, Williams G, Bertolini M, Paus R, Philpott MP
Scientific reports 2021 Oct 21;11(1):20761
Scientific reports 2021 Oct 21;11(1):20761
Functionalized Gadofullerene Ameliorates Impaired Glycolipid Metabolism in Type 2 Diabetic Mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2021 Oct 20;
Journal of genetics and genomics = Yi chuan xue bao 2021 Oct 20;
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice.
Ren YR, Ye YL, Feng Y, Xu TF, Shen Y, Liu J, Huang SL, Shen JH, Leng Y
Acta pharmacologica Sinica 2021 Nov;42(11):1834-1846
Acta pharmacologica Sinica 2021 Nov;42(11):1834-1846
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
Wen YC, Liu CL, Yeh HL, Chen WH, Jiang KC, Tram VTN, Hsiao M, Huang J, Chen WY, Liu YN
British journal of cancer 2021 Nov 24;
British journal of cancer 2021 Nov 24;
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke.
Geng X, Shen J, Li F, Yip J, Guan L, Rajah G, Peng C, DeGracia D, Ding Y
Molecular neurobiology 2021 May;58(5):2309-2321
Molecular neurobiology 2021 May;58(5):2309-2321
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771
Journal of food biochemistry 2021 Jul;45(7):e13771
LncRNA GA-Binding Protein Transcription Factor Subunit Beta-1 Antisense RNA 1 Inhibits Renal Carcinoma Growth Through an MiR-1246/Phosphoenolpyruvate Carboxykinase 1 Pathway.
Gao S, Zhang F, Sun H, Yang X
OncoTargets and therapy 2020;13:6827-6836
OncoTargets and therapy 2020;13:6827-6836
PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
Shi L, An S, Liu Y, Liu J, Wang F
OncoTargets and therapy 2020;13:2613-2627
OncoTargets and therapy 2020;13:2613-2627
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, Chen J, Gong Z, Liu Z, Xiao W
Food & function 2020 Sep 23;11(9):8369-8379
Food & function 2020 Sep 23;11(9):8369-8379
Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress.
Liu F, Zhu S, Ni L, Huang L, Wang K, Zhou Y
Endocrine 2020 Jan;67(1):87-94
Endocrine 2020 Jan;67(1):87-94
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z
Nature 2020 Apr;580(7804):530-535
Nature 2020 Apr;580(7804):530-535
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Ma J, Wei K, Liu J, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B
Nature communications 2020 Apr 14;11(1):1769
Nature communications 2020 Apr 14;11(1):1769
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance.
Wu M, Liao L, Jiang L, Zhang C, Gao H, Qiao L, Liu S, Shi D
Biomaterials 2019 Nov;222:119457
Biomaterials 2019 Nov;222:119457
Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output.
Liu J, Yang K, Yang J, Xiao W, Le Y, Yu F, Gu L, Lang S, Tian Q, Jin T, Wei R, Hong T
EBioMedicine 2019 Mar;41:73-84
EBioMedicine 2019 Mar;41:73-84
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.
Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S
Journal of the American Society of Nephrology : JASN 2019 Jul;30(7):1192-1205
Journal of the American Society of Nephrology : JASN 2019 Jul;30(7):1192-1205
A novel immunodeficient rat model supports human lung cancer xenografts.
He D, Zhang J, Wu W, Yi N, He W, Lu P, Li B, Yang N, Wang D, Xue Z, Zhang P, Fan G, Zhu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):140-150
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):140-150
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.
Thapa D, Xie B, Manning JR, Zhang M, Stoner MW, Huckestein BR, Edmunds LR, Zhang X, Dedousis NL, O'Doherty RM, Jurczak MJ, Scott I
Physiological reports 2019 Apr;7(8):e14043
Physiological reports 2019 Apr;7(8):e14043
Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats.
Niu L, Chen Q, Hua C, Geng Y, Cai L, Tao S, Ni Y, Zhao R
Journal of animal science and biotechnology 2018;9:26
Journal of animal science and biotechnology 2018;9:26
Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Wang Y, Yan S, Xiao B, Zuo S, Zhang Q, Chen G, Yu Y, Chen D, Liu Q, Liu Y, Shen Y, Yu Y
Diabetes 2018 Sep;67(9):1748-1760
Diabetes 2018 Sep;67(9):1748-1760
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Qi X, Guo Y, Song Y, Yu C, Zhao L, Fang L, Kong D, Zhao J, Gao L
Diabetologia 2018 May;61(5):1180-1192
Diabetologia 2018 May;61(5):1180-1192
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Yang S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J, Yang X
Scientific reports 2018 Jun 14;8(1):9158
Scientific reports 2018 Jun 14;8(1):9158
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
Role of AMPD2 in impaired glucose tolerance induced by high fructose diet.
Hudoyo AW, Hirase T, Tandelillin A, Honda M, Shirai M, Cheng J, Morisaki H, Morisaki T
Molecular genetics and metabolism reports 2017 Dec;13:23-29
Molecular genetics and metabolism reports 2017 Dec;13:23-29
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
Vieira P, Cameron J, Rahikkala E, Keski-Filppula R, Zhang LH, Santra S, Matthews A, Myllynen P, Nuutinen M, Moilanen JS, Rodenburg RJ, Rolfs A, Uusimaa J, van Karnebeek CDM
Molecular genetics and metabolism 2017 Apr;120(4):337-341
Molecular genetics and metabolism 2017 Apr;120(4):337-341
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Santra S, Cameron JM, Shyr C, Zhang L, Drögemöller B, Ross CJ, Wasserman WW, Wevers RA, Rodenburg RJ, Gupte G, Preece MA, van Karnebeek CD
Molecular genetics and metabolism 2016 May;118(1):21-7
Molecular genetics and metabolism 2016 May;118(1):21-7
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y
Scientific reports 2015 Jun 10;5:11219
Scientific reports 2015 Jun 10;5:11219
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R
PloS one 2014;9(8):e105504
PloS one 2014;9(8):e105504
Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.
Mauvoisin D, Wang J, Jouffe C, Martin E, Atger F, Waridel P, Quadroni M, Gachon F, Naef F
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 7;111(1):167-72
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 7;111(1):167-72
Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens.
Guo F, Zhang Y, Su L, Ahmed AA, Ni Y, Zhao R
Poultry science 2013 Oct;92(10):2737-44
Poultry science 2013 Oct;92(10):2737-44
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The PCK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PCK1. This antibody recognizes human,mouse,rat antigen. The PCK1 antibody has been validated for the following applications: ELISA, WB analysis.