PPP1R8

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

Description

Protein phosphatase 1 regulatory subunit 8

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (27830782 - 27851676)

Ensembl ID

ENSG00000117751  (ver. 103.38)

Orthologs

Mouse Ppp1r8: ENSMUSG00000028882

UniProt

Q12972

neXtProt

NX_Q12972

Human splice variants
Mouse splice variants

Protein structure