ZFHX3

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

Zinc finger homeobox 3

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

16 (72782885 - 73891871)

Ensembl ID

ENSG00000140836  (ver. 103.38)

Orthologs

Mouse Zfhx3: ENSMUSG00000038872

UniProt

Q15911

neXtProt

NX_Q15911

Human splice variants
Mouse splice variants

Protein structure