PA1-028

antibody from Invitrogen Antibodies

Targeting: PPID CYP-40

Western blot (Supportive data in Antibodypedia)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

PA1-028

Provider

Invitrogen Antibodies

Product name

Cyclophilin 40 Polyclonal Antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

PA1-028 detects cyclophilin D (CyPD) in rat, hamster, canine, mouse, and human tissues.

Concentration

1 mg/mL

References

Submitted references

Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion.

Cuillerier A, Honarmand S, Cadete VJJ, Ruiz M, Forest A, Deschênes S, Beauchamp C, LSFC Consortium, Charron G, Rioux JD, Des Rosiers C, Shoubridge EA, Burelle Y
Human molecular genetics 2017 Aug 15;26(16):3186-3201

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Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead.

Liu G, Wang ZK, Wang ZY, Yang DB, Liu ZP, Wang L
Archives of toxicology 2016 May;90(5):1193-209

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Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter.

Nichols CE, Shepherd DL, Knuckles TL, Thapa D, Stricker JC, Stapleton PA, Minarchick VC, Erdely A, Zeidler-Erdely PC, Alway SE, Nurkiewicz TR, Hollander JM
American journal of physiology. Heart and circulatory physiology 2015 Dec 15;309(12):H2017-30

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Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.

Hansson MJ, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, Tanoue T, Omi A, Shibasaki F, Shimazu M, Ikeda Y, Uchino H, Elmér E
Journal of neurotrauma 2011 Jan;28(1):143-53

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Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location.

Williamson CL, Dabkowski ER, Baseler WA, Croston TL, Alway SE, Hollander JM
American journal of physiology. Heart and circulatory physiology 2010 Feb;298(2):H633-42

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Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes.

Dabkowski ER, Baseler WA, Williamson CL, Powell M, Razunguzwa TT, Frisbee JC, Hollander JM
American journal of physiology. Heart and circulatory physiology 2010 Aug;299(2):H529-40

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Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury.

Wang X, Carlsson Y, Basso E, Zhu C, Rousset CI, Rasola A, Johansson BR, Blomgren K, Mallard C, Bernardi P, Forte MA, Hagberg H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Feb 25;29(8):2588-96

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Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction.

Dabkowski ER, Williamson CL, Hollander JM
Free radical biology & medicine 2008 Sep 15;45(6):855-65

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Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D.

Csukly K, Ascah A, Matas J, Gardiner PF, Fontaine E, Burelle Y
The Journal of physiology 2006 Jul 1;574(Pt 1):319-27

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Effects of permeability transition inhibition and decrease in cytochrome c content on doxorubicin toxicity in K562 cells.

De Oliveira F, Chauvin C, Ronot X, Mousseau M, Leverve X, Fontaine E
Oncogene 2006 Apr 27;25(18):2646-55

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Modulation of mitochondrial transition pore components by thyroid hormone.

Yehuda-Shnaidman E, Kalderon B, Bar-Tana J
Endocrinology 2005 May;146(5):2462-72

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P
The Journal of biological chemistry 2005 May 13;280(19):18558-61

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Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria.

De Marchi U, Campello S, Szabò I, Tombola F, Martinou JC, Zoratti M
The Journal of biological chemistry 2004 Sep 3;279(36):37415-22

Western blot

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Figure 1 shows a Western blot of CyPD on rat heart extract using Product # PA1-028.

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Figure 2 shows a Western blot of CyPD on rat brain extract using Product # PA1-028.

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

NULL