CHRDL2

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

Description

Chordin like 2

Tissue specificity

Tissue enhanced (endometrium , gallbladder, lymphoid tissue, smooth muscle)

Subcell location

Vesicles

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (74696429 - 74731426)

Ensembl ID

ENSG00000054938  (ver. 103.38)

Orthologs

Mouse Chrdl2: ENSMUSG00000030732

UniProt

Q6WN34

neXtProt

NX_Q6WN34

Human splice variants
Mouse splice variants

Protein structure