NB100-59787

Stubbe M, Mai J, Paulus C, Stubbe HC, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay R, Groitl P, Nevels M, Dobner T, Schreiner S
mBio 2020 Mar 17;11(2)

ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity.

Hofmann S, Mai J, Masser S, Groitl P, Herrmann A, Sternsdorf T, Brack-Werner R, Schreiner S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Apr;7(8):1902130

Proteomic characterization of arsenic and cadmium exposure in bladder cells.

Chen YT, Ou Yang WT, Juang HH, Chen CL, Chen HW, Tsui KH, Chang YH, Tsai CH, Hsueh C, Liao WC
Rapid communications in mass spectrometry : RCM 2020 Apr;34 Suppl 1:e8578

Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites.

Lång A, Eriksson J, Schink KO, Lång E, Blicher P, Połeć A, Brech A, Dalhus B, Bøe SO
Nucleus (Austin, Tex.) 2017 Jul 4;8(4):404-420

The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1.

Yao K, Wu Y, Chen Q, Zhang Z, Chen X, Zhang Y
PloS one 2016;11(9):e0162832

Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.

Berscheminski J, Brun J, Speiseder T, Wimmer P, Ip WH, Terzic M, Dobner T, Schreiner S
Oncogene 2016 Jun 16;35(24):3178-89

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S
Oncogene 2016 Jan 7;35(1):69-82

KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.

Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S
Journal of virology 2016 Jan 15;90(2):930-46

An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies.

Komatsu T, Nagata K, Wodrich H
Journal of virology 2016 Feb 1;90(3):1657-67

KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.

Chen HY, Hu JY, Chen TH, Lin YC, Liu X, Lin MY, Lang YD, Yen Y, Chen RH
Oncogene 2015 Oct 1;34(40):5141-51

Promyelocytic leukemia bodies tether to early endosomes during mitosis.

Palibrk V, Lång E, Lång A, Schink KO, Rowe AD, Bøe SO
Cell cycle (Georgetown, Tex.) 2014;13(11):1749-55

HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.

Coltella N, Percio S, Valsecchi R, Cuttano R, Guarnerio J, Ponzoni M, Pandolfi PP, Melillo G, Pattini L, Bernardi R
EMBO molecular medicine 2014 May;6(5):640-50

Sp100 isoform-specific regulation of human adenovirus 5 gene expression.

Berscheminski J, Wimmer P, Brun J, Ip WH, Groitl P, Horlacher T, Jaffray E, Hay RT, Dobner T, Schreiner S
Journal of virology 2014 Jun;88(11):6076-92

The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription.

Berscheminski J, Groitl P, Dobner T, Wimmer P, Schreiner S
Journal of virology 2013 Jan;87(2):965-77

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes.

Schreiner S, Bürck C, Glass M, Groitl P, Wimmer P, Kinkley S, Mund A, Everett RD, Dobner T
Nucleic acids research 2013 Apr 1;41(6):3532-50

Covalent protein modification with ISG15 via a conserved cysteine in the hinge region.

Bade VN, Nickels J, Keusekotten K, Praefcke GJ
PloS one 2012;7(6):e38294

Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity.

Chiantore MV, Vannucchi S, Accardi R, Tommasino M, Percario ZA, Vaccari G, Affabris E, Fiorucci G, Romeo G
PloS one 2012;7(5):e36909

A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP
The Journal of clinical investigation 2012 Sep;122(9):3088-100

Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection.

Sivachandran N, Wang X, Frappier L
Journal of virology 2012 Jun;86(11):6146-58

Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma.

Sivachandran N, Dawson CW, Young LS, Liu FF, Middeldorp J, Frappier L
Journal of virology 2012 Jan;86(1):60-8

Study of early events during herpes simplex virus type 1 infection by confocal microscopy.

Everett RD
Methods (San Diego, Calif.) 2011 Oct;55(2):144-52

Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes.

Lee AK, Smart JL, Rubinstein M, Low MJ, Tse A
Endocrinology 2011 May;152(5):1901-10

The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies.

Jung M, Finnen RL, Neron CE, Banfield BW
Journal of virology 2011 Jun;85(11):5301-11

SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML.

Wimmer P, Schreiner S, Everett RD, Sirma H, Groitl P, Dobner T
Oncogene 2010 Oct 7;29(40):5511-22

Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.

Sivachandran N, Cao JY, Frappier L
Journal of virology 2010 Nov;84(21):11113-23

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: PML Protein Antibody [NB100-59787] - Detection of Human PML on HeLa whole cell lysate using NB100-59787. PML was also immunoprecipitated by rabbit anti-PML antibodies NB100-59788 and another CDC16/APC6 Ab.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: PML Protein Antibody [NB100-59787] - FFPE section of human breast carcinoma. Affinity purified rabbit anti-PML used at a dilution of 1:500

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: PML Protein Antibody [NB100-59787] - IHC analysis of a formalin fixed and paraffin embedded tissue section of human stomach using 1:50 dilution of PML antibody. The signal was developed using HRP-labeled secondary with DAB reagent followed by hematoxylin counterstaining. This antibody generated an expected strong nuclear staining in most of the cells in the glandular as well as the connective tissue. The cells showed some cytoplasmic signal also which was much weaker than the nuclear staining.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry: PML Protein Antibody [NB100-59787] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- PML used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB