SP140

This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

Description

SP140 nuclear body protein

Tissue specificity

Group enriched (intestine, lymphoid tissue)

Subcell location

Nucleoli fibrillar center, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

2 (230203110 - 230313215)

Ensembl ID

ENSG00000079263  (ver. 103.38)

Orthologs

Mouse Sp100: ENSMUSG00000026222

UniProt

Q13342

neXtProt

NX_Q13342

Human splice variants
Mouse splice variants

Protein structure