TSHZ3

This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]

Description

Teashirt zinc finger homeobox 3

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

19 (31149979 - 31349436)

Ensembl ID

ENSG00000121297  (ver. 103.38)

Orthologs

Mouse Tshz3: ENSMUSG00000021217

UniProt

Q63HK5

neXtProt

NX_Q63HK5

Human splice variants
Mouse splice variants

Protein structure