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NUP214
Nucleoporin 214CAIN, CAN, D9S46E, N214
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Top validated antibodies |
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| Novus Biologicals |  NB100-2244 |
1 references | Polyclonal |
WB
ICC
IP
IHC
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| NSJ Bioreagents | RQ5673 |
Polyclonal |
WB
EL
ICC
FC
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| Boster Biological Technology | A02408 |
Polyclonal |
WB
EL
ICC
FC
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| antibodies-online | ABIN151666 |
1 references | Polyclonal |
WB
ICC
IP
IHC
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| Invitrogen Antibodies | PA5-114371 |
Polyclonal |
WB
EL
ICC
FC
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