BS8334

antibody from Bioworld Technology, Inc
Targeting: MXI1 bHLHc11, MAD2, MXD2, MXI
Provider product page for BS8334
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8334 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MXI1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MXI1.
Description
It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1, Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad-binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MXI1 protein structure - BS8334 shown in red.