ARTN

This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

Description

Artemin

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

1 (43933320 - 43937240)

Ensembl ID

ENSG00000117407  (ver. 103.38)

Orthologs

Mouse Artn: ENSMUSG00000028539

UniProt

Q5T4W7

neXtProt

NX_Q5T4W7

Human splice variants
Mouse splice variants

Protein structure