KCNAB1

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]

Description

Potassium voltage-gated channel subfamily A member regulatory beta subunit 1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (156037701 - 156539138)

Ensembl ID

ENSG00000169282  (ver. 103.38)

Orthologs

Mouse Kcnab1: ENSMUSG00000027827

UniProt

Q14722

neXtProt

NX_Q14722

Human splice variants
Mouse splice variants

Protein structure