WDR33

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

WD repeat domain 33

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli fibrillar center

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (127701027 - 127811187)

Ensembl ID

ENSG00000136709  (ver. 103.38)

Orthologs

Mouse Wdr33: ENSMUSG00000024400

UniProt

Q9C0J8

neXtProt

NX_Q9C0J8

Human splice variants
Mouse splice variants

Protein structure