SPACA1

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

Description

Sperm acrosome associated 1

Tissue specificity

Tissue enriched (testis)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (88047841 - 88066838)

Ensembl ID

ENSG00000118434  (ver. 103.38)

Orthologs

Mouse Spaca1: ENSMUSG00000028264

UniProt

Q9HBV2

neXtProt

NX_Q9HBV2

Human splice variants
Mouse splice variants

Protein structure