GABRR2

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016]

Description

Gamma-aminobutyric acid type A receptor subunit rho2

Tissue specificity

Tissue enriched (retina)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

6 (89254464 - 89315299)

Ensembl ID

ENSG00000111886  (ver. 103.38)

Orthologs

Mouse Gabrr2: ENSMUSG00000023267

UniProt

P28476

neXtProt

NX_P28476

Human splice variants
Mouse splice variants

Protein structure