DDX54

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

DEAD-box helicase 54

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Golgi apparatus

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (113157173 - 113185479)

Ensembl ID

ENSG00000123064  (ver. 103.38)

Orthologs

Mouse Ddx54: ENSMUSG00000029599

UniProt

Q8TDD1

neXtProt

NX_Q8TDD1

Human splice variants
Mouse splice variants

Protein structure