TECTA

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]

Description

Tectorin alpha

Tissue specificity

Low tissue specificity

Predicted location

Membrane, Secreted in other tissues

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (121101243 - 121191490)

Ensembl ID

ENSG00000109927  (ver. 103.38)

Orthologs

Mouse Tecta: ENSMUSG00000037705

UniProt

O75443

neXtProt

NX_O75443

Human splice variants
Mouse splice variants

Protein structure