KLK7

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Description

Kallikrein related peptidase 7

Tissue specificity

Group enriched (esophagus, skin)

Subcell location

Nuclear membrane, Plasma membrane

Predicted location

Intracellular, Secreted in other tissues

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

19 (50976468 - 50984099)

Ensembl ID

ENSG00000169035  (ver. 103.38)

Orthologs

Mouse Klk7: ENSMUSG00000030713

UniProt

P49862

neXtProt

NX_P49862

Human splice variants
Mouse splice variants

Protein structure