SCN3B

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Description

Sodium voltage-gated channel beta subunit 3

Tissue specificity

Tissue enhanced (brain, pituitary gland)

Subcell location

Intermediate filaments, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (123629187 - 123655244)

Ensembl ID

ENSG00000166257  (ver. 103.38)

Orthologs

Mouse Scn3b: ENSMUSG00000049281

UniProt

Q9NY72

neXtProt

NX_Q9NY72

Human splice variants
Mouse splice variants

Protein structure