Antibody data

Product number
11-1020 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-14-3-3 sigma Antibody
Antibody type
Polyclonal
Description
14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 Sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to Gamma-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.
Reactivity
Human
Host
Rabbit
Antigen sequence
Full length recombinant 14-3-3 sigm
a protein was used as the immunogen
for this antibody.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
SFN protein structure - 11-1020 shown in red.