BS6961

antibody from Bioworld Technology, Inc
Targeting: ADIPOQ ACDC, ACRP30, adiponectin, apM1, GBP28
Provider product page for BS6961
Western blot
Immunohistochemistry

Antibody data

Product number
BS6961 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Acrp30 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Acrp30.
Description
Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes. It is secreted into the blood and exists in three major forms: a low molecular weight trimer, a medium molecular weight hexamer and a high molecular weight multimer. Adiponectin levels are decreased in obese and insulin-resistant mice and humans, suggesting that this adipokine is critical to maintain insulin sensitivity. Adiponectin stimulates the phosphorylation of AMPKÏ« at Thr172 and activates AMPK in skeletal muscle. It also stimulates glucose uptake in myocytes. The block of AMPK activation by a dominant-negative AMPKÏ«2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimulates glucose uptake and increases insulin sensitivity through its action on AMPK. Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway. Mutations that render adiponectin unable to form high molecular weight multimers are associated with human diabetes, indicating the importance of multimerization for adiponectin activity.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ADIPOQ protein structure - BS6961 shown in red.