17-3359-41

antibody from Invitrogen Antibodies

Targeting: NCR1 CD335, LY94, NK-p46, NKP46

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

17-3359-41

Provider

Invitrogen Antibodies

Product name

CD335 (NKp46) Monoclonal Antibody (9E2), APC, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: This 9E2 monoclonal antibody reacts with human CD335, which is also known as NKp46. Expressed on NK cells, CD335 is a member of the natural cytotoxicity receptor family that also includes NKp30 and NKp44. This type I transmembrane glycoprotein is involved in activating and expanding resting NK cells following interaction with dendritic cells to eliminate tumor and virus-infected (e.g., influenza) cells. CD335 also interacts with pancreatic beta cells during the development of type I diabetes.

Antibody clone number

9E2

Concentration

5 µL/Test

References

Submitted references

The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients.

Zhang H, Huang C, Chen X, Li L, Liu S, Li Y, Zhang Y, Zeng Y, Hu L
Genes & diseases 2020 Jun;7(2):283-289

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Induction of the Lytic Cycle Sensitizes Epstein-Barr Virus-Infected B Cells to NK Cell Killing That Is Counteracted by Virus-Mediated NK Cell Evasion Mechanisms in the Late Lytic Cycle.

Williams LR, Quinn LL, Rowe M, Zuo J
Journal of virology 2016 Jan 15;90(2):947-58

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Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes.

Santer DM, Wiedeman AE, Teal TH, Ghosh P, Elkon KB
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 15;188(2):902-15

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Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46.

Gur C, Enk J, Kassem SA, Suissa Y, Magenheim J, Stolovich-Rain M, Nir T, Achdout H, Glaser B, Shapiro J, Naparstek Y, Porgador A, Dor Y, Mandelboim O
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 15;187(6):3096-103

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Proteolytic activation of the cytotoxic phenotype during human NK cell development.

Meade JL, Wilson EB, Holmes TD, de Wynter EA, Brett P, Straszynski L, Ballard PA, Trapani JA, McDermott MF, Cook GP
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 15;183(2):803-13

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NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection.

Draghi M, Pashine A, Sanjanwala B, Gendzekhadze K, Cantoni C, Cosman D, Moretta A, Valiante NM, Parham P
Journal of immunology (Baltimore, Md. : 1950) 2007 Mar 1;178(5):2688-98

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) PE (Product # 12-0567-42) and Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (left) or Anti-Human CD335 (NKp46) APC (right). Cells in the lymphocyte gate were used for analysis.