GRIN2C

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Description

Glutamate ionotropic receptor NMDA type subunit 2C

Tissue specificity

Tissue enhanced (brain, thyroid gland)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

17 (74842023 - 74861504)

Ensembl ID

ENSG00000161509  (ver. 103.38)

Orthologs

Mouse Grin2c: ENSMUSG00000020734

UniProt

Q14957

neXtProt

NX_Q14957

Human splice variants
Mouse splice variants

Protein structure