IL12RB2

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

Description

Interleukin 12 receptor subunit beta 2

Tissue specificity

Tissue enhanced (brain, placenta)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (67307364 - 67398724)

Ensembl ID

ENSG00000081985  (ver. 103.38)

Orthologs

Mouse Il12rb2: ENSMUSG00000018341

UniProt

Q99665

neXtProt

NX_Q99665

Human splice variants
Mouse splice variants

Protein structure