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Protein structure
CTLA4
Cytotoxic T-lymphocyte associated protein 4CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| R&D Systems |  AF-386-PB |
2 references | Polyclonal |
WB
ICC
FC
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| Invitrogen Antibodies | 12-1529-41 |
30 references | Monoclonal |
FC
OA
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| Novus Biologicals | AF-386-PB |
3 references | Polyclonal |
WB
ICC
FC
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| Abnova Corporation | H00001493-M06 |
1 references | Monoclonal |
WB
EL
ICC
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| LSBio | LS-C669065 |
Monoclonal |
WB
EL
ICC
IHC
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