P4HA1

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Prolyl 4-hydroxylase subunit alpha 1

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Vesicles, Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (73007217 - 73096974)

Ensembl ID

ENSG00000122884  (ver. 103.38)

Orthologs

Mouse P4ha1: ENSMUSG00000019916

UniProt

P13674

neXtProt

NX_P13674

Human splice variants
Mouse splice variants

Protein structure