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Cell line expression
Protein structure
IL6R
Interleukin 6 receptorCD126
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| R&D Systems |  AF1830 |
10 references | Polyclonal |
WB
EL
IHC
FC
BN
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| Novus Biologicals | AF1830 |
11 references | Polyclonal |
WB
IHC
FC
BN
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| Proteintech Group | 23457-1-AP |
10 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | AHR0061 |
10 references | Monoclonal |
EL
IP
IHC
FC
BN
OA
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| GeneTex | GTX76550 |
Monoclonal |
EL
ICC
IP
IHC
FC
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