Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS7203 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL6R polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL6R.
- Description
- IL-6 activates intracellular signaling through binding a receptor consisting of a ligand-binding protein (IL-6RÏ«) and a second protein. IL-6 first binds to IL-6RÏ« (also known as gp80), which subsequently associates with a gp130 dimer. The active signaling complex consists of, at minimum, IL-6, IL-6RÏ« and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6RÏ«, namely sIL-6RÏ«, is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-to-cell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of IL6R polyclonal antibody