BS7203

antibody from Bioworld Technology, Inc
Targeting: IL6R CD126
Provider product page for BS7203
Western blot
Immunohistochemistry

Antibody data

Product number
BS7203 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL6R polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL6R.
Description
IL-6 activates intracellular signaling through binding a receptor consisting of a ligand-binding protein (IL-6RÏ«) and a second protein. IL-6 first binds to IL-6RÏ« (also known as gp80), which subsequently associates with a gp130 dimer. The active signaling complex consists of, at minimum, IL-6, IL-6RÏ« and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6RÏ«, namely sIL-6RÏ«, is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-to-cell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL6R protein structure - BS7203 shown in red.