ADAMTS4

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 4

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Nuclear speckles

Predicted location

Intracellular, Membrane, Secreted to extracellular matrix

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (161184302 - 161199054)

Ensembl ID

ENSG00000158859  (ver. 103.38)

Orthologs

Mouse Adamts4: ENSMUSG00000006403

UniProt

O75173

neXtProt

NX_O75173

Human splice variants
Mouse splice variants

Protein structure