Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
ALPL
Alkaline phosphatase, biomineralization associatedHOPS, TNALP, TNAP, TNSALP
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Top validated antibodies |
|||||
| R&D Systems |  AF2910 |
6 references | Polyclonal |
WB
ICC
IP
IHC
FC
|
|
| Novus Biologicals | AF2910 |
12 references | Polyclonal |
WB
ICC
IP
IHC
FC
|
|
| Proteintech Group | 11187-1-AP |
32 references | Polyclonal |
WB
EL
IHC
FC
|
|
| antibodies-online | ABIN1105293 |
2 references | Monoclonal |
WB
EL
IHC
FC
|
|
| Invitrogen Antibodies | MA5-24845 |
1 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider