RGS18

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Description

Regulator of G protein signaling 18

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (192158462 - 192185815)

Ensembl ID

ENSG00000150681  (ver. 103.38)

Orthologs

Mouse Rgs18: ENSMUSG00000026357

UniProt

Q9NS28

neXtProt

NX_Q9NS28

Human splice variants
Mouse splice variants

Protein structure