Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- orb18147 - Provider product page
- Provider
- Biorbyt
- Proper citation
- Biorbyt Cat#orb18147, RRID:AB_10766779
- Product name
- ROCK2 antibody
- Antibody type
- Polyclonal
- Description
- Rabbit Polyclonal to ROCK2. Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. (2003) concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 μg
- Concentration
- Lyophilized Powder
- Storage
- Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
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Supportive validation
- Submitted by
- Biorbyt (provider)
- Main image
- Experimental details
- Western Blot analysis of cell lysate using ROCK2 antibody
Supportive validation
- Submitted by
- Biorbyt (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded human intestine cancer using ROCK2 antibody