CDK19

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Description

Cyclin dependent kinase 19

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (110609978 - 110815958)

Ensembl ID

ENSG00000155111  (ver. 103.38)

Orthologs

Mouse Cdk19: ENSMUSG00000038481

UniProt

Q9BWU1

neXtProt

NX_Q9BWU1

Human splice variants
Mouse splice variants

Protein structure