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Protein structure
MLKL
Mixed lineage kinase domain like pseudokinaseFLJ34389
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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| Proteintech Group |  21066-1-AP |
24 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | H00197259-M02 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-105678 |
2 references | Polyclonal |
WB
IHC
OA
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| GeneTex | GTX107538 |
11 references | Polyclonal |
WB
IP
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| Affinity Biosciences | DF7412 |
Polyclonal |
WB
EL
ICC
IHC
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