PSMA2

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

Description

Proteasome 20S subunit alpha 2

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

7 (42916828 - 42932185)

Ensembl ID

ENSG00000106588  (ver. 103.38)

Orthologs

Mouse Psma2: ENSMUSG00000015671

UniProt

P25787

neXtProt

NX_P25787

Human splice variants
Mouse splice variants

Protein structure