SPTBN1

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Spectrin beta, non-erythrocytic 1

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (54456317 - 54671446)

Ensembl ID

ENSG00000115306  (ver. 103.38)

Orthologs

Mouse Sptbn1: ENSMUSG00000020315

UniProt

Q01082

neXtProt

NX_Q01082

Human splice variants
Mouse splice variants

Protein structure