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Protein structure
PTPRM
Protein tyrosine phosphatase receptor type MhR-PTPu, PTPRL1, RPTPU
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NB100-79867 |
1 references | Polyclonal |
EL
IHC
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| Cell Signaling Technology, Inc | 4485 |
1 references | Monoclonal |
WB
IP
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| antibodies-online | ABIN256739 |
1 references | Polyclonal |
EL
IHC
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| Biorbyt | orb956328 |
Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | MA5-31874 |
Monoclonal |
WB
EL
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