FBXO25

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

F-box protein 25

Tissue specificity

Tissue enhanced (testis)

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

8 (406428 - 477967)

Ensembl ID

ENSG00000147364  (ver. 103.38)

Orthologs

Mouse Fbxo25: ENSMUSG00000038365

UniProt

Q8TCJ0

neXtProt

NX_Q8TCJ0

Human splice variants
Mouse splice variants

Protein structure