BS7840

antibody from Bioworld Technology, Inc
Targeting: MOAP1 MAP-1, PNMA4
Provider product page for BS7840
Western blot
Immunohistochemistry

Antibody data

Product number
BS7840 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MOAP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MOAP1.
Description
MOAP1 (modulator of apoptosis 1) is a 352 amino acid protein encoded by the human gene MOAP1. MOAP1 belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. When MOAP1 is associated with RASSF1, it promotes a Bax conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. MOAP1 is a homo-dimer and, under normal circumstances, is held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to Bax. MOAP1 will also bind to Bcl-2 and Bcl-x.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MOAP1 protein structure - BS7840 shown in red.