Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7840 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- MOAP1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human MOAP1.
- Description
- MOAP1 (modulator of apoptosis 1) is a 352 amino acid protein encoded by the human gene MOAP1. MOAP1 belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. When MOAP1 is associated with RASSF1, it promotes a Bax conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. MOAP1 is a homo-dimer and, under normal circumstances, is held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to Bax. MOAP1 will also bind to Bcl-2 and Bcl-x.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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