CABYR

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Description

Calcium binding tyrosine phosphorylation regulated

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

18 (24138987 - 24161600)

Ensembl ID

ENSG00000154040  (ver. 103.38)

Orthologs

Mouse Cabyr: ENSMUSG00000024430

UniProt

O75952

neXtProt

NX_O75952

Human splice variants
Mouse splice variants

Protein structure