FGL1

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

Description

Fibrinogen like 1

Tissue specificity

Tissue enriched (liver)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (17864380 - 17910365)

Ensembl ID

ENSG00000104760  (ver. 103.38)

Orthologs

Mouse Fgl1: ENSMUSG00000031594

UniProt

Q08830

neXtProt

NX_Q08830

Human splice variants
Mouse splice variants

Protein structure