LATS2

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Description

Large tumor suppressor kinase 2

Tissue specificity

Low tissue specificity

Subcell location

Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

13 (20973036 - 21061586)

Ensembl ID

ENSG00000150457  (ver. 103.38)

Orthologs

-

UniProt

Q9NRM7

neXtProt

NX_Q9NRM7

Human splice variants

Protein structure