CDH12

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]

Description

Cadherin 12

Tissue specificity

Tissue enhanced (brain, retina)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

5 (21750673 - 22853344)

Ensembl ID

ENSG00000154162  (ver. 103.38)

Orthologs

Mouse Cdh12: ENSMUSG00000040452

UniProt

P55289

neXtProt

NX_P55289

Human splice variants
Mouse splice variants

Protein structure