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Protein structure
AXIN1
Axin 1PPP1R49
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| antibodies-online |  ABIN393560 |
5 references | Monoclonal |
WB
EL
ICC
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| Proteintech Group | 16541-1-AP |
5 references | Polyclonal |
WB
EL
IHC
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| Novus Biologicals | NBP2-61695 |
Monoclonal |
WB
EL
ICC
FC
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| Cell Signaling Technology, Inc | 2074 |
1 references | Monoclonal |
WB
IP
IHC
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| Invitrogen Antibodies | 34-5900 |
11 references | Polyclonal |
WB
ICC
IP
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