ABR

This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

Description

ABR activator of RhoGEF and GTPase

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (1003518 - 1229738)

Ensembl ID

ENSG00000159842  (ver. 103.38)

Orthologs

Mouse Abr: ENSMUSG00000017631

UniProt

Q12979

neXtProt

NX_Q12979

Human splice variants
Mouse splice variants

Protein structure