ADAMTS12

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 12

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Mitochondria

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (33523535 - 33892019)

Ensembl ID

ENSG00000151388  (ver. 103.38)

Orthologs

Mouse Adamts12: ENSMUSG00000047497

UniProt

P58397

neXtProt

NX_P58397

Human splice variants
Mouse splice variants

Protein structure