LOXL2

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Description

Lysyl oxidase like 2

Tissue specificity

Tissue enhanced (smooth muscle)

Subcell location

Nucleoplasm

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (23296897 - 23425328)

Ensembl ID

ENSG00000134013  (ver. 103.38)

Orthologs

Mouse Loxl2: ENSMUSG00000034205

UniProt

Q9Y4K0

neXtProt

NX_Q9Y4K0

Human splice variants
Mouse splice variants

Protein structure