ALOX5AP

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Description

Arachidonate 5-lipoxygenase activating protein

Tissue specificity

Group enriched (bone marrow, lung, lymphoid tissue)

Predicted location

Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13 (30713478 - 30764426)

Ensembl ID

ENSG00000132965  (ver. 103.38)

Orthologs

Mouse Alox5ap: ENSMUSG00000060063

UniProt

P20292

neXtProt

NX_P20292

Human splice variants
Mouse splice variants

Protein structure